根据对健康儿童应用的13个参考方程,获得的预测螺旋计值的百分比差异
Viviana Aguirre-Camposano1, Javier Mallol1
1Department of Paediatric Respiratory Medicine, Hospital El Pino, University of Santiago de Chile (USACH), Santiago, Chile.
概括
螺旋测量预测方程显示儿童肺功能值的显著差异. 这些差异凸显了对儿科患者群体区域特定方程的需求.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统生理学 呼吸系统生理学
- 生物统计学 生物统计学
背景情况:
- 关于健康儿童的各种预测方程 (PE) 衍生出的螺旋计值差异的数据有限.
- 精确的螺旋测量对于诊断和监测儿科呼吸系统疾病至关重要.
研究的目的:
- 量化使用十三种不同的PE在健康的智利儿童中获得的百分比预测 (PP) 肺功能值的差异.
- 将这些PE与GLI-2012参考方程进行比较,并包括种族中立的GLI-2022方程.
主要方法:
- 分析了一组208名7至17岁的智利健康儿童.
- 对FVC,FEV1,FEF25-75%和FEV1/FVC的PP值是使用13个PE计算出来的.
- 统计分析将每个PE的PP值与GLI-2012参考值进行比较.
主要成果:
- 在男孩和女孩的PEs中观察到PP值的广泛差异.
- GLI-2012与其他PE之间的显著差异在女孩中更为频繁 (p < 0.001).
- 与GLI-2012相比,GLI-2022的种族中立方程也显示出了变化.
结论:
- 通过不同的PE计算的螺旋计PP值存在实质性的变化,包括GLI-2022.
- 研究结果表明,这对儿童肺功能评估有潜在的解释性和临床影响.
- 需要在拉丁美洲进行标准化,多中心的研究,以确定适合区域儿科人口的PE.
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