微环境中的增强相互作用加速了TACE后与HBV相关的HCC的阴暗预后
Libo Wang1,2, Jiahui Cao1, Zaoqu Liu3
1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Hepatology communications
|October 4, 2024
概括
对于晚期肝细胞癌 (HCC) 的转动脉化学栓塞 (TACE) 改变了瘤微环境,增加了炎症和细胞相互作用. NABP1可能会识别那些对TACE不良反应的患者.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 超动脉化血栓化 (TACE) 是晚期肝细胞癌 (HCC) 的首要治疗方法.
- 关于TACE如何影响瘤微环境的研究有限.
- 了解这些变化对于改善HCC治疗结果至关重要.
研究的目的:
- 研究TACE在与HBV相关的HCC中诱导的微环境变化.
- 确定与TACE反应和预后相关的生物标志物.
- 阐明特定细胞相互作用在TACE后进展中的作用.
主要方法:
- 用TACE和没有TACE的HCC标本的单细胞RNA测序.
- 分析了3个大规模的多中心散装RNA测序队列.
- 通过表型实验进行生物标志物功能的体外验证.
主要成果:
- TACE诱导了一种促炎性瘤微环境,并增加了瘤异质性.
- 在TACE后观察到恶性肝细胞,中性粒细胞和CD8+ T细胞之间的相互作用增加.
- 增加NABP1+恶性肝细胞与TACE反应和预后不佳相关;NABP1可以作为生物标志物.
结论:
- 在TACE后的微环境变化,包括增强的细胞相互作用,有助于瘤的进展.
- NABP1显示出作为早期识别TACE反应较弱患者的生物标志物的潜力.
- 针对微环境调制可以提高TACE在HCC治疗中的疗效.
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