检查在明确的负评价性压力诱导过程中对皮质醇和α-氨酶反应性的下垂体-垂体-上腺轴遗传变异
Alessandra R Grillo1, Lisa R Starr2, Suzanne Vrshek-Schallhorn1
1Department of Psychology, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
概括
垂体-垂体-上腺 (HPA) 轴多部位遗传特征得分 (MGPS) 并没有显著改变皮质醇或交感神经系统对实验室压力的反应性. 对压力生物标志物的遗传影响可能比以前假设的更复杂.
科学领域:
- 神经内分泌学神经内分泌学
- 行为遗传学 行为遗传学
背景情况:
- 之前的研究将HPA轴遗传变异 (MGPS) 与压力下的抑郁风险联系起来.
- 选择HPA MGPS变体是因为它们有可能增加皮质醇反应性.
- 在HPA轴和交感神经系统 (SNS) 之间对压力反应的基因影响的相互作用是研究不足的.
研究的目的:
- 调查HPA MGPS是否能缓和实验室压力与HPA轴 (皮质醇) 或SNS (唾液α-氨酶,sAA) 反应性之间的关系.
- 检查新兴成年人对生理应激反应的遗传贡献.
主要方法:
- 新兴成年人 (N=152) 接受了特里尔社会压力测试变异或对照条件.
- 为了计算HPA MGPS,收集了DNA.
- 为了测量皮质醇和sAA水平,反复采集唾液样本.
主要成果:
- HPA MGPS并没有显著缓解压力状态和皮质醇反应性之间的关联.
- 此外,HPA MGPS也没有显著缓解压力状态和sAA反应性之间的关联.
- 个别的多形态表现出相反的,无意义的效应,在总体上互相取消.
结论:
- HPA MGPS对皮质醇反应性的影响并不像预期的那样直接.
- 对生物标志物应激反应性的遗传影响可能取决于特定的压力因素和相关的遗传变异.
- 需要进一步的研究来了解HPA和SNS对压力的反应的复杂遗传基础.
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