印度神经管缺陷的负担:系统性审查和元分析
Anuvi Sinha1, Ponmani P2, Hirok Chakraborty3
1Obstetrics and Gynecology Department, Sadar Hospital, Ranchi, Jharkhand, India.
概括
神经管缺陷 (NTDs) 在印度是一个严重的问题,每1000名新生儿中总发病率为9.46. 迫切需要采取预防策略,以应对区域差异和NTD日益增长的趋势.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 遗传异常 是一种先天性异常.
背景情况:
- 神经管缺陷 (NTDs) 是印度的一个重大公共卫生挑战,其特点是缺乏综合数据.
- 了解NTD的流行病情景对于开发有效的干预措施至关重要.
研究的目的:
- 通过元分析确定印度各地NTD的综合流行率.
- 为了确定印度NTD流行率的区域差异.
主要方法:
- 在PubMed和Embase数据库上进行了系统的文献搜索,截至2023年10月1日.
- 系统审查和元分析首选报告项目 (PRISMA) 检查清单指导了在PROSPERO注册的研究协议.
- 使用DerSimonian-Laird方法与随机效应模型计算聚合患病率,结合子组和灵敏度分析.
主要成果:
- 在1129篇已识别的文章中,有27篇符合元分析的选择标准.
- 总体NTD的患病率估计为每1000例出生中有9.46例 (95%CI:8.0110.91).
- 观察到显著的异质性 (I2 = 99.15%),这表明流行率估计的变化很大.
结论:
- 该研究揭示了近几十年来NTD的增长趋势,印度各地存在显著的区域差异.
- 迫切需要全面的预防策略,包括宣传,产前查,叶酸补充和食品强化.
- 特定于区域的有针对性的研究对于确定和实施有效的NTD预防计划至关重要.
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