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Thanin Asawavichienjinda¹, Nutchawan Jittapiromsak², Andrew Blumenfeld³

¹Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, 1873 Rama IV Road, Pathum Wan District, Bangkok, 10330, Thailand. thanin.a@chula.ac.th.

Pain and therapy

|October 4, 2024

概括

一个罕见的脑动脉血管收缩病例发生在Galcanezumab后,这是一个与抗素基因相关的抗 (CGRP) 单克隆抗体,没有典型的可逆脑血管收缩综合征 (RCVS) 症状. 这突显了CGRP抑制剂的一种潜在的,尽管很少见的副作用.

科学领域:

神经学神经学
药理学药理学是指药理学的学科.
放射学放射学是一门学科.

背景情况:

反色素基因相关 (CGRP) 单克隆抗体用于偏头痛治疗.
与这些抗体相关的罕见副作用是可逆大脑血管收缩综合征 (RCVS).
CGRP单克隆抗体的目标是CGRP配体或受体.

研究的目的:

报告在加尔坎祖马布 (galcanezumab) 给药后发生的大脑动脉血管收缩的病例.
调查抗CGRP单克隆抗体的潜在不良影响.
为了记录成像发现和临床过程在一个患者经历血管收缩后galcanezumab.

主要方法:

一个40岁的女性患有高频发作性偏头痛的病例报告.
给出加尔坎祖马布的加载剂量.
连续脑磁共振血管学 (MRA) 扫描以记录大脑动脉血管收缩.

主要成果:

患者在加尔坎祖马布治疗后出现过渡性神经症状 (麻木),但没有头痛.
大脑MRA揭示了脑中和脑后动脉的细分动脉收缩.
血管收缩在六个月内部分消失;没有出现典型的RCVS表现.

结论:

大脑动脉血管收缩是抗CGRP单克隆抗体 (如加尔坎祖马布) 的潜在罕见副作用.
这一案例突出了发生在没有经典RCVS症状的情况下的血管收缩.
需要进一步的研究来了解这种不良事件的机制和患病率.

关键词:

这是CGRP的CGRP.案例报告案例报告大脑动脉血管收缩脑动脉血管收缩加尔坎祖马布 (Galcanezumab) 是一种药物.偏头痛是一种偏头痛.偏头痛带有光环的偏头痛

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