三胞胎神经疼痛及其并发症:全国性疾病轨迹研究研究
Jacob Worm1, Isabella Friis Jørgensen2, Ólafur Birgir Davídsson1,3,4
1Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Pain
|October 4, 2024
概括
三神经疼痛 (TN) 与27种疾病有关,包括缺血性中风. 像卡巴马西平这样的第一线TN治疗增加了中风风险,突出了对TN患者血管风险评估的需要.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 三神经疼痛 (TN) 是一种使人虚弱的面部疼痛障碍,对其风险因素和并发症的了解有限.
- 肌痛性肌痛不成比例地影响女性,其特点是严重的,单边的面部疼痛发作.
研究的目的:
- 使用全国疾病轨迹,识别与三角神经疼痛 (TN) 暂时相关的疾病.
- 调查TN,其治疗方法和中风风险之间的关联,包括多基因风险评分.
主要方法:
- 分析了丹麦国家患者登记册 (1994-2018) 中720万个人的全国数据.
- 7141名TN个体与1万名匹配的对照进行了比较,以确定同时发生的疾病.
- 考克斯回归分析,以评估与特定TN药物相关的中风风险 (卡巴马泽平,氧卡马泽平与 gabapentin,普雷加巴林,拉莫特里金).
主要成果:
- 诊断TN与27种疾病有关,其中包括18种先前和9种后续疾病.
- 在TN和缺血性中风之间发现了显著的关联 (相对风险为1.55).
- 卡巴马兹或牛炭治疗显著增加缺血性中风风险 (风险比1.78),而多基因性中风风险没有任何关联.
结论:
- 三神经疼痛的诊断与缺血性中风的发病率较高有关.
- 对TN的第一线治疗方法,特别是卡巴马泽平和卡马泽平,与中风风险增加有关.
- 对于被诊断患有三角神经疼痛的人来说,建议对血管风险因素进行例行评估.
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