描述一生中女性血管和激素变化:一个横截面分析
Megan M Wenner1, Ninette Shenouda1, Leena Shoemaker2
1Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, United States.
American journal of physiology. Heart and circulatory physiology
|October 4, 2024
概括
女性的血管功能障碍大约在47岁左右开始,其标志是内皮功能下降和大动脉硬性增加. 卵泡刺激激素和孕,而不是雌激素,部分解释了这些与年龄相关的血管变化.
科学领域:
- 心血管科学 心血管科学
- 生殖内分泌学 生殖内分泌学
- 血管生理学 血管生理学
背景情况:
- 血管功能障碍,包括内皮功能障碍和大动脉硬,是心血管疾病 (CVD) 的关键风险因素.
- 在整个生命周期中,女性血管变化的发病和荷尔蒙调解仍然不完全理解.
- 识别与年龄相关的血管变化及其荷尔蒙影响对于女性心血管疾病预防策略至关重要.
研究的目的:
- 确定健康妇女内皮功能和大动脉硬性的年龄相关断点.
- 研究生殖激素 (雌激素,卵泡刺激激素,孕激素) 在与年龄相关的血管变化中的调解作用.
主要方法:
- 招募了140名18至70岁的健康女性.
- 通过使用超声波进行手臂动脉流介导扩张 (FMD) 来评估内皮功能.
- 测量了大动脉硬度,使用带-大腿脉冲波速率 (cfPWV) 和量化生殖激素水平.
主要成果:
- 在47岁后,内皮功能 (FMD) 显著下降.
- 大动脉硬 (cfPWV) 显示出一个断点,并在48岁后增加.
- 途径分析表明,卵泡刺激激素和孕激素部分调解了年龄与FMD的关系,而雌激素则没有.
结论:
- 健康的女性体验到内皮功能下降和大动脉硬度增加在47-48岁左右,更年期之前.
- 卵泡刺激激素和孕激素的升高,而不是雌激素的下降,与与年龄相关的内皮功能障碍有关.
- 这些发现突出了女性血管衰老的特定荷尔蒙影响,为心血管风险评估提供了目标.
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