胰岛素样生长因子1受体表达与编程死亡配体1表达以及非小细胞肺癌的低生存率相关
Hiroaki Nagamine1,2, Masakazu Yashiro3, Megumi Mizutani2
1Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
PloS one
|October 4, 2024
概括
胰岛素样生长因子1受体 (IGF1R) 表达与早期非小细胞肺癌 (NSCLC) 的生存率较差有关. 阳性IGF1R也与NSCLC患者的编程死亡配体1 (PD-L1) 表达相关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 胰岛素样生长因子1受体 (IGF1R) 与癌症生长和转移有关.
- 它在非小细胞肺癌 (NSCLC) 复发和手术后预后方面的确切作用尚不清楚.
- 了解IGF1R的影响对于改进治疗策略至关重要.
研究的目的:
- 研究IGF1R表达与NSCLC手术后复发之间的关联.
- 评估IGF1R与长期生存结果之间的关系.
- 探索IGF1R与编程死亡带1 (PD-L1) 表达之间的相关性.
主要方法:
- 分析了782名NSCLC患者的队列.
- 评估IGF1R和PD-L1表达的手术样本的免疫染.
- 统计分析将表达水平与无复发生存率 (RFS) 和整体生存率 (OS) 相关联.
主要成果:
- 阳性IGF1R表达在35.8%的患者中被观察到,与明显更糟糕的RFS和OS相关.
- 在早期NSCLC (0-1) 中,IGF1R阳性与较差的生存率密切相关.
- PD-L1表达 (12.8%的患者) 与IGF1R阳性病例有显著的关联.
结论:
- IGF1R表达是早期NSCLC预后不佳的重要指标.
- IGF1R可以指导早期肺癌的术后治疗决策.
- 这些发现突出了IGF1R,降低生存率和NSCLC中的PD-L1表达之间的联系.
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