长期暴露于与交通有关的空气污染和心脏代谢表现型之间的关联:基于MRI数据的分析
Margarethe Woeckel1,2, Susanne Rospleszcz1,2,3, Kathrin Wolf1
1Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Environmental science & technology
|October 4, 2024
概括
长期暴露于与交通有关的空气污染 (TRAP) 与早期心脏变化和心脏脂肪增加有关. 这些影响在妇女和糖尿病患者中更为显著,表明亚临床心脏代谢疾病的发展.
科学领域:
- 环境健康 环境健康
- 心脏病学 心脏病学
- 代谢性疾病 代谢性疾病
背景情况:
- 长期暴露于与交通有关的空气污染 (TRAP) 与心脏代谢疾病有关.
- 对于TRAP在心脏代谢疾病的亚临床阶段的作用尚不清楚.
研究的目的:
- 研究长期TRAP暴露与亚临床心脏代谢表型之间的关联.
- 使用磁共振成像 (MRI) 来详细表型心脏和脂肪组织.
主要方法:
- 对400名KORA队列参与者的横截面分析.
- 心室和脂肪组织 (AT) 的MRI衍生的表型.
- 土地利用回归模型估计了长期TRAP暴露 (NO2,PNC).
主要成果:
- 暴露于TRAP与左心室 (LV) 壁厚度的降低有关.
- 增加的二氧化 (NO2) 与减少的LV壁厚度有关.
- 增加的粒子数度 (PNC) 与心脏AT升高相关.
- 在女性和患有糖尿病的参与者中,相关性更强.
结论:
- 长期暴露于TRAP与亚临床心脏代谢变化有关.
- 研究结果表明,TRAP有助于心脏代谢疾病的早期阶段.
- 代谢易受伤害的子组,如女性和糖尿病患者,表现出更高的易感性.
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