三糖和抑郁症之间的关联:系统性审查和元分析
Di-Ru Xu1, Xi Gao1, Li-Bo Zhao2,3
1Department of Dermatology, University‑Town Hospital of Chongqing Medical University, Chongqing, China.
PloS one
|October 4, 2024
概括
重度抑郁症 (MDD) 与较高的甘油三 (TG) 水平有关,增加心血管风险. 这一元分析证实,与健康对照组相比,MDD患者的TG升高,突出了关键的代谢差异.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 心血管健康 心血管健康
背景情况:
- 抑郁症经常与失脂症有关.
- 脱脂症会增加中风和冠状动脉心脏病的风险.
- 了解抑郁症中的代谢变化对于全面的患者护理至关重要.
研究的目的:
- 在重大抑郁症 (MDD) 中对外周血甘油三化物 (TG) 度的证据进行定量合成,与健康对照 (HCs) 相比.
- 评估MDD患者和HC患者之间TG水平的整体差异.
- 探索TG水平中异质性的潜在来源.
主要方法:
- 在PubMed,EMBASE,PsycINFO和Cochrane数据库中进行了系统的文献搜索,直到2023年3月.
- 使用随机效应的元分析,将TG度数据 (标准化平均差异 - SMD) 结合起来.
- 进行了子组分析和元回归来研究异质性.
主要成果:
- 包括38项涉及2604名MDD患者和3272名HC患者的研究.
- 分析显示,与HC相比,MDD患者的TG水平显著更高 (SMD = 0.31,p < 0.01).
- 观察到显著的异质性 (I2 = 85%),子组分析表明年龄,BMI和药物使用的影响.
结论:
- 在患有重度抑郁症的个体中,周围血液中的甘油三水平显著升高.
- 抑郁症中TG升高可能会导致心血管和脑血管事件的风险增加.
- 需要进一步的研究来阐明抑郁症和代谢失调之间的复杂相互作用.
相关概念视频
Depression: Overview
224
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
224
Depressive Disorders: Etiology
55
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
55
Blood Studies for Cardiovascular System III: Serum Lipid Profile
135
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
135
Antidepressant Drugs: MAOIs and Other Agents
200
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
200
Depressive Disorders: MDD and Dysthymia
65
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
65
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
328
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
328


