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脑动脉瘤的隔离和焦点治疗使用界面流体捕获

Maria Khoury¹, Tirosh Mekler¹, Mark Epshtein^1,2

¹Department of Biomedical Engineering, Technion - IIT, Haifa 32000, Israel.

Science advances

|October 4, 2024

概括

这项研究引入了一种基于流体的新策略,用于局部静脉内治疗. 这种方法使用不可混合的液体精确准和治疗脑动脉瘤,为局部治疗提供了一种新方法.

科学领域:

生物医学工程生物医学工程
流体动力学流体动力学
干预心脏病学干预心脏病学

背景情况:

当前局部化血管内治疗通常使用固体植入物或分散剂.
在特定的血管部位有效的栓塞和局部药物输送仍然具有挑战性.

研究的目的:

开发和验证一种基于流体的策略,用于精确的血管内治疗局部化.
为了证明界面流动在脑动脉瘤部位的限制治疗的潜力.

主要方法:

利用计算建模和实验验证,定位不混合的流体.
将该策略应用于人类动脉瘤模型,包括宽类型.
在动脉瘤腔内展示了局部化的细胞染色和基于水凝的栓塞.

主要成果:

成功定位了一种不可混合的液相,以密封动脉瘤腔.
在动脉瘤模型中实现了局限和焦点治疗.
在患者特定的动脉瘤模型中验证了该策略用于栓塞.

结论:

接口流动驱动的策略使血管内治疗的强大局部化成为可能.
这种基于液体的方法为局部治疗心血管疾病 (如动脉瘤) 提供了一个有希望的替代方案.

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