透皮药物输送系统 (TDDS):最近的进展和失败模式
Mohsen Ghaferi1, Seyed Ebrahim Alavi2, Khanh Phan2
1Department of Chemical Engineering, Islamic Azad University, Shahrood Branch, Shahrood, Semnan 9WVR+757, Iran.
Molecular pharmaceutics
|October 4, 2024
概括
透皮药物输送系统 (TDDS) 是一种方便,非侵入性的方法,可以通过皮肤给药. 本综述探讨了TDDS的有效性,风险和失败模式,以改善治疗开发.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 透皮药物递送系统 (TDDS) 或贴片提供了一种非侵入性的药物递送方法.
- TDDS以可控的速度将特定剂量直接释放到血液中,绕过口服代谢.
- 现有的TDDS用于各种药物,目前正在研究生物交付.
研究的目的:
- 审查当前关于医学TDDS在通过皮肤递送药物的疗效的文献.
- 在TDDS设计和开发中识别潜在的风险和故障模式.
- 概述了减轻发现风险的策略,以确保治疗质量.
主要方法:
- 关于通过皮肤递送药物系统的综合文献综述.
- 对TDDS疗效的分析,包括药物释放动力学和生物可用性.
- 检查TDDS中报告的故障模式和相关的风险因素.
主要成果:
- 与传统方法相比,TDDS在方便性和减少侵入性方面具有显著的优势.
- 审查确定了关键的故障模式,包括粘附问题,药物泄漏和释放率不足.
- 降低风险的策略集中在材料选择,配方优化和制造过程控制上.
结论:
- TDDS是有效药物输送的有希望的平台,包括生物药物.
- 了解和解决故障模式对于开发安全有效的透皮疗法至关重要.
- 在TDDS设计和开发中的积极风险管理对于临床成功至关重要.
更多相关视频
18:57Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
46.3K
10:33A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
Published on: February 23, 2018
25.2K
相关概念视频
Drug Delivery: Overview
278
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
278
Drug Delivery: Miscellaneous Routes
329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
Non-Oral Extravascular Drug Absorption Routes
202
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
202
Drug Distribution: Overview
146
Drug distribution within the body is a dynamic process involving the movement of a drug in two directions across various compartments: from the bloodstream into tissues (tissue uptake) and from tissues back into the bloodstream (tissue release or redistribution). This process is passive and primarily driven by two variables: the concentration gradient between the bloodstream and the extravascular tissues and the drug's ability to cross the cell membrane.
Initially, the free drug in the...
Initially, the free drug in the...
146
Drug Delivery: Enteral Route
386
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
386
Drug Delivery: Parenteral Route
440
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
440
