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Updated: Jun 11, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Published on: March 28, 2017

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再组合CYP3A4变体对伊马替尼布代谢的作用和相互作用 in vitro

Jie Chen1, Yingying Hu1, Jinyu Hu1

  • 1The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|October 4, 2024
PubMed
概括

这项研究检查了26种cytochrome P450 3A4 (CYP3A4) 变体和影响意马替尼的代谢的药物相互作用. 大多数变体改变了伊马替尼的清除值,有些人表现出活性下降,影响了个性化癌症治疗.

关键词:
其他CYP3A4变体卡博桑提尼布 (Cabozantinib) 是一种药物.伊马替尼布 (Imatinib) 的使用情况代谢过程中的代谢.微观体是微观体的组成部分.

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