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胎儿皮下脂肪厚度与胰岛素耐药性之间的相关性通过带血在分娩后立即进行分析

Sul Lee¹, Hyun-Jin Kim¹, Hyun-Joo Lee¹

¹Department of Obstetrics and Gynecology, Pusan National University Hospital, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan, Republic of Korea; Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, Republic of Korea.

European journal of obstetrics, gynecology, and reproductive biology

|October 4, 2024

概括

在出生前测量的胎儿皮下组织厚度可以预测新生儿的胰岛素耐药性,特别是在经过良好管理的妊娠糖尿病 (GDM) 中. 这种超声波方法为评估婴儿代谢健康提供了宝贵的工具.

科学领域:

围产科和新生儿医学
代谢和内分泌疾病在怀孕期间
医学超声波应用医学超声波应用

背景情况:

孕期糖尿病 (GDM) 影响胎儿的葡萄糖代谢和新生儿的结果.
准确评估新生儿胰岛素耐药性对于早期干预至关重要.
胎儿人类学可以提供有关产后代谢适应的见解.

研究的目的:

评估胎儿皮下组织 (SCT) 厚度是否通过超声波测量,与分娩前与分娩后的葡萄糖代谢相关.
评估孕期母亲胰岛素抵抗对胎儿SCT和新生儿代谢状态的影响.
为了比较这些参数的孕妇与良好控制的GDM和那些正常的葡萄糖代谢.

主要方法:

在分娩前对胎儿SCT厚度的超声波测量和分娩后的口径测量.
对带血糖和胰岛素水平的分析,以计算对胰岛素耐药性的恒温模型评估 (HOMA-IR).
使用统计测试 (t-test,Wilcoxon,Fisher的精确测试) 和相关性分析 (Pearson的) 进行20名GDM患者和97名对照组之间的参数比较.

主要成果:

与对照组相比,患有GDM的孕妇的胎儿SCT和新生儿皮显著加厚.
在患有GDM的母亲的新生儿中,带血糖,胰岛素和HOMA-IR的升高表明葡萄糖代谢受损.
在GDM组中,发现胎儿腹部SCT厚度和新生儿葡萄糖水平 (r=0.64) 和HOMA-IR (r=0.48) 之间存在显著的正相关性.

结论:

产前胎儿SCT厚度是新生儿胰岛素抵抗的一个有价值的预测指标.
这种非侵入性超声波方法特别有用,用于识别有效管理GDM的母亲的新生儿的风险,即使没有明显的宏观性质.
胎儿SCT测量为高风险怀孕中评估新生儿代谢健康提供了一种实用方法.

关键词:

胎儿皮下组织胎儿皮下组织孕期糖尿病是一种糖尿病.葡萄糖不耐受症是什么胰岛素耐药性胰岛素耐药性是一种新生儿的皮肤

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