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基于辅助抗PD-1疗法的黑色素瘤复发的性质和治疗方法

Rachel Woodford¹, Janet McKeown¹, Lotte L Hoeijmakers²

¹Melanoma Institute Australia, University of Sydney, 45 Rocklands Road, Wollstonecraft, Sydney, NSW, Australia.

European journal of cancer (Oxford, England : 1990)

|October 4, 2024

概括

黑色素瘤患者在辅助抗PD-1疗法后经常复发,经常是在治疗期间. 尽管对这些复发进行了各种管理策略,但结果仍然很差.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
黑色素瘤研究黑色素瘤研究

背景情况:

辅助抗PD-1疗法是切除的II-IV阶段黑色素瘤的标准.
大约50%的患者在5年内出现复发.
关于治疗后辅助疗法的黑色素瘤复发最佳管理策略的数据有限.

研究的目的:

调查黑色素瘤患者的复发模式和结果,这些患者接受了辅助抗PD-1疗法.
评估不同管理策略对无复发生存率 (RFS2) 和整体生存率 (OS) 的影响.

主要方法:

多中心,国际,回顾性队列研究.
包括在2022年1月之前接受辅助抗PD-1治疗并随后复发的被切除的II-IV阶段黑色素瘤患者.
收集有关人口统计,疾病特征,复发模式,管理和结果的数据.

主要成果:

分析了711名患者,63%的人在接受抗PD-1治疗时复发.
仅用局部治疗治疗的局部区域复发 (LR) 的12个月RFS2为25%.
远程复发 (DR) 经常用全身疗法 (86%) 治疗,使用联合抗CTLA-4和抗PD-1疗法,显示出改善无进展生存率 (PFS).

结论:

在辅助抗PD-1疗法后,黑色素瘤复发通常发生在早期和治疗期间.
结果通常很差,无论复发地点,时间或随后的治疗.
需要进一步的研究来改善这些患者的管理和治疗结果.

关键词:

一个辅助的辅助.抗PD-1疗法是一种治疗.远距离的复发情况免疫治疗是一种免疫疗法.免疫疗法耐药性免疫疗法耐药性地方地区复发情况.黑色素瘤是一种黑色素瘤.复发性疾病是复发性疾病.

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