低度至中度的肺部神经内分泌瘤. 一个单一的中心真实世界体验
Jacqueline Martin1, Mohammad Alrehaili2, Horia Marginean3
1University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Cancer treatment and research communications
|October 4, 2024
概括
经过手术治疗的肺神经内分泌瘤 (LNETs) 患者的生存率很好. 先进的LNET的结果较差,表明需要更好的治疗指南.
科学领域:
- 在瘤学瘤学.
- 医学瘤学 医学瘤学
背景情况:
- 肺神经内分泌瘤 (LNETs) 是一种罕见的,异质的瘤群,发病率不断增加.
- 了解诊断,治疗和生存对于管理LNET至关重要.
研究的目的:
- 调查低度至中度LNET患者的诊断,治疗和生存模式.
- 根据疾病阶段和治疗方式来评估结果.
主要方法:
- 在加拿大癌症中心对59名低度至中度LNET患者的回顾性图表审查.
- 分析治疗方法,包括手术,放射,化疗和全身疗法.
主要成果:
- 手术治疗的患者的5年整体存活率 (OS) 为83%,而非手术患者的这一比例为44%.
- 第四期疾病的5年生存率为39%.
- 晚期/无法切除的疾病 (n=32) 接受了息性全身治疗,使用各种一线,二线和三线疗法,包括化疗,索马托斯塔丁类似物,Everolimus和capecitabine/temozolomide.
结论:
- 通过手术切除的LNET具有有利的生存结果.
- 无法操作或发达的LNET与较差的生存率有关.
- 对于晚期LNET的最佳治疗顺序尚未确立,因此需要基于证据的指导方针.
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