中基因作为与年龄相关的变化和乳腺瘤发生率增加的驱动因素
Pengze Yan1, Ernesto Rojas Jimenez1, Zheqi Li1
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Cancer cell
|October 4, 2024
概括
老龄化通过改变乳腺细胞并促进癌前变化而增加乳腺癌风险. 这项研究确定了midkine (Mdk) 作为这一过程中的关键调节剂,将其与瘤发育的增加联系起来.
科学领域:
- 老年学是一门学科.
- 癌症生物学 癌症生物学
- 分子生物学分子生物学
背景情况:
- 老龄化是癌症的主要风险因素,但驱动这种关联的特定分子机制尚未完全理解.
- 乳腺随着年龄的增长而发生显著的变化,这可能会影响癌症的易感性.
研究的目的:
- 用单细胞多组学研究大鼠乳腺中与年龄相关的分子和细胞变化.
- 确定与年龄相关的乳腺癌风险增加的关键分子媒介.
主要方法:
- 在不同年龄段对老鼠乳腺进行单细胞多组学分析.
- 基因表达概况和途径分析.
- 在体内实验中对年轻大鼠进行中治疗,并评估乳腺瘤发生.
主要成果:
- 在乳腺中鉴定了与年龄相关的上皮细胞增殖和光细胞身份丧失的增加.
- 在老老老鼠中发现了一种新的光原体群体,这些老鼠表现出癌前分子形状.
- 发现midkine (Mdk) 随着年龄的增长而升级,并被确定为这些与年龄相关的祖先的调节者.
- 证明年轻大鼠中治疗可以复制与年龄相关的变化,并增强乳腺瘤的发展.
- 在人类血液和乳腺组织中,随着年龄的增长观察到中水平的增加,与乳腺癌风险相关.
结论:
- 衰老会诱导乳腺中显著的细胞和分子变化,使其倾向于癌症发病.
- 中基因 (Mdk) 是乳腺瘤发生的年龄相关增加的关键调解者.
- 准中可能提供一种策略,以减轻与年龄相关的乳腺癌风险.
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