相关实验视频

Updated: Jun 11, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

在儿科急性髓性白血病中进行干细胞移植的简化和强大的风险分层模型

Hua Yang¹, Yang Xun¹, Yali Shen²

¹Laboratory for Excellence in Systems Biomedicine of Pediatric Oncology, Department of Pediatric Hematology and Oncology, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Basic Medicine, School of Medicine, Foshan University, Foshan, Guangdong Province, China.

Cell reports. Medicine

|October 4, 2024

概括

在CR1阶段接受干细胞移植 (SCT) 的儿科急性髓性白血病 (pAML) 患者的新预后模型改善了风险分层. 这种模型使用年龄,KMT2A重新排列和MRD1来增强候选人选择,以获得更好的移植结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
儿科医学儿科医学

背景情况:

在儿科急性髓性白血病 (pAML) 中,干细胞移植 (SCT) 的疗效受到当前预后模型的限制.
预测SCT疗效和选择合适的pAML候选物仍然具有挑战性.

研究的目的:

为CR1阶段的pAMLSCT开发一个细胞分子风险分层独立的预后模型.
加强移植前决策和pAML SCT候选人选择.

主要方法:

开发了一个预后模型,包括年龄,KMT2A重新排列 (KMT2A-r) 和在第1课程结束时的最小残留疾病 (MRD1).
在内部和四个外部队伍中验证了该模型,这些队伍与各种源和捐赠者进行了验证.
通过包括FLT3/ITD等位基比来改进模型,以改进候选人选择.

主要成果:

该pAML SCT模型有效地将患者分为低,中,高风险组.
跨多个队伍的验证证实了该模型的稳定性和通用性.
纳入FLT3/ITD等位基比进一步提高了候选人选择的预测准确性.

结论:

已经开发了一个简单,强大的CR1阶段pAML SCT风险分层模型.
该模型有助于风险分层,并为移植前的决策提供信息.
这种精细的模型有助于在pAML中选择合适的SCT候选人.

关键词:

FLT3/ITD 的等位基比.最少残留疾病的最小残留疾病.儿科急性髓性白血病儿科急性髓性白血病风险分层模型的风险分层模型.干细胞移植干细胞移植

更多相关视频

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

相关概念视频

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...