在聚合物同类介导下形成水凝微针,用于可控制的通过皮肤递送药物
Xinwei Fu1, Hong Xian2, Chuanlan Xia1
1Key Laboratory of Luminescence Analysis and Molecular Sensing, School of Materials and Energy, Southwest University, Chongqing 400715, China; Yibin Academy of Southwest University, Yibin 644000, China.
International journal of pharmaceutics
|October 4, 2024
概括
研究人员开发了新的聚乙烯甘二烯酸盐 (PEGDA) 微针 (TP-X MNs),没有化学交叉连接剂. 这些可调节的微针可以为生物医学应用提供可控的药物释放.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 聚乙烯甘醇) 二烯酸盐 (PEGDA) 微针 (MNs) 是用于控制药物输送的水凝装置.
- 目前的方法通常依赖于具有低于最佳生物安全性配置的交叉连接剂.
- 需要简化和更安全的方法来控制MN交联密度.
研究的目的:
- 开发具有可调节交叉连接密度的PEGDA微针 (TP-X MNs),没有化学交叉连接剂.
- 研究聚合物成分比对机械性能和药物释放的影响.
- 探索双层PEGDA MNs在定制药物输送方面的潜力.
主要方法:
- 使用不同分子重量的两个PEGDA聚合物同类物合成TP-X MNs.
- 改变了PEGDA组件的重量比例,以控制交叉连接密度.
- 评估了机械性能和药物释放动力学.
- 制造和表征的新型双层PEGDA MNs.
主要成果:
- 根据PEGDA成分比率,TP-X MNs表现出可调节的机械性能和药物释放概况.
- 所有TP-X MNs都在336小时内持续释放药物.
- 累积释放率在6.24%至40.93%之间.
- 双层PEGDA MNs允许在每个层中定制药物加载和释放.
结论:
- 成功开发了一种创新方法,用于创建具有可调节交叉连接密度的PEGDA MNs,避免化学交叉连接器.
- TP-X MNs提供了一个多功能平台,用于可调节释放动力学的可控药物输送.
- 这种方法扩大了PEGDA微针在生物医学领域的应用范围.
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