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Updated: Jun 11, 2025

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Microbubble Fabrication of Concave-porosity PDMS Beads
Published on: December 15, 2015
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通过同化研究微球制造的相分离步骤中的关键因素
Yuelei Wei1, Jiyuan Yu1, Bingqi Xiong1
1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 211198, P.R. China.
International journal of pharmaceutics
|October 4, 2024
概括
这项研究阐明了用于微球制备的联合化中的关键因素. 控制乳酸:葡萄糖比率和最大限度地减少滴滴凝聚对于狭窄的颗粒大小分布至关重要.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 生物技术是生物技术.
背景情况:
- 凝聚是一种广泛用于微球制备的方法.
- 对同化中的关键阶段分离步骤给予了不够的关注.
研究的目的:
- 为了阐明影响微球制备的同化过程中的相分离步骤的关键因素.
- 为了优化微球特征,特别是狭窄的尺寸分布.
主要方法:
- 聚合物溶液的热力学,以确定相位平衡,二极线和度关系.
- 计算流体动力学 (CFD) 用于分析螺旋设计和状态.
- 粘度测量和乳液理论,以了解分相过程中的乳液行为.
主要成果:
- 乳酸:葡萄糖比率显著影响相位分离.
- 开发了一种方法来计算相位组成和质量.
- 驱动器的设计和空隙会影响颗粒大小的分布.
- 衰弱的同体液滴凝聚是狭窄尺寸分布的关键.
结论:
- 乳酸:葡萄糖酸共聚合物 (PLGA) 度在同聚合物阶段和颗粒大小分布对于分离阶段至关重要.
- 了解和控制这些因素可以通过同化优化微球的准备.
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