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相关概念视频

Typical Model Studies01:30

Typical Model Studies

344
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
344
Modeling and Similitude01:12

Modeling and Similitude

248
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
248
Design Example: Creating a Hydraulic Model of a Dam Spillway01:21

Design Example: Creating a Hydraulic Model of a Dam Spillway

135
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
135

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相关实验视频

Updated: Jun 11, 2025

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
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开发一种高保真度数字双胞胎,使用离散元件方法进行连续的直接压缩过程. 第1部分 1. 校准工作流程的工作流程.

Dalibor Jajcevic1, Johan Remmelgas1, Peter Toson1

  • 1Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

International journal of pharmaceutics
|October 4, 2024
PubMed
概括

创建了一个用于直接压缩药物制造的高保真度数字双胞胎. 该工具使用材料特征学准确预测过程结果,帮助制定控制策略.

关键词:
连续制造 连续制造制造控制战略 控制策略在 DEM 校准中使用 DEM 校准在DEM模拟中使用DEM模拟器.数字双胞胎 数字双胞胎 数字双胞胎居住时间的分布.

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相关实验视频

Last Updated: Jun 11, 2025

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科学领域:

  • 制药工程 制药工程
  • 计算流体动力学的流体动力学.
  • 材料科学 材料科学 材料科学

背景情况:

  • 直接压缩是制药制造中的一个关键过程.
  • 开发强大的控制策略需要准确的过程模拟.
  • 数字双胞胎为虚拟测试和优化提供了一个强大的平台.

研究的目的:

  • 开发一种高保真度的数字双胞胎,用于直接压缩制药产品的制造.
  • 用实验数据验证数字双胞胎的预测能力.
  • 为制药过程中的离散元件方法 (DEM) 模型建立一个校准方法.

主要方法:

  • 开发一个模拟制药设备和直接压缩过程的数字双胞胎平台.
  • 使用散装密度,压缩,剪切细胞和旋转鼓测试进行详细的材料表征.
  • 使用实验数据应用和校准一个连贯的DEM接触模型.
  • 模拟系统响应与API度变化实验结果的比较.

主要成果:

  • 校准方法成功地区分了具有不同流动性的材料批量.
  • 小规模的材料特性测试准确地预测了连续制造中的停留时间分布.
  • 数字双胞胎对DEM接触参数表现出敏感性,影响了过程预测.

结论:

  • 一个经过验证的高保真数字双胞胎可以有效地支持直接压缩制造的控制策略的设计和测试.
  • 拟议的校准方法使得使用基本材料属性的过程行为能够准确预测.
  • 这种方法有助于更好地理解和优化连续制药制造工艺.