免疫媒介性风湿性疾病与健康成年人的肌肉强度比较:一个元分析
Rafaela Cavalheiro do Espírito Santo1, Leonardo Peterson Dos Santos2, Geiziane Melo1
1Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania.
Journal of the American Medical Directors Association
|October 4, 2024
概括
免疫媒介性风湿性疾病 (IMRD) 患者的肌肉强度降低,尤其是女性. 低强度与疾病持续时间,活动和身体功能有关,需要有针对性的干预措施.
科学领域:
- 类风湿病学 类风湿病学
- 肌肉骨健康 肌肉骨健康
- 临床研究 临床研究
背景情况:
- 免疫媒介性类风湿性疾病 (IMRDs) 经常与肌肉力量的减弱有关.
- 了解肌肉力量缺陷及其IMRD的临床相关性对于患者管理至关重要.
研究的目的:
- 与健康对照人群相比,系统地审查和元分析IMRD患者的肌肉强度.
- 探索IMRD群体中低肌肉强度和临床特征之间的关系.
主要方法:
- 对病例控制研究的系统审查和元分析.
- 在2023年11月之前进行全面的数据库搜索 (Embase,MEDLINE,Web of Science,Cochrane).
- 随机效应模型元分析以比较IMRD患者和年龄/性别匹配的对照之间的肌肉强度.
主要成果:
- 对26项研究 (2661名参与者) 的元分析显示,与对照组相比,IMRD女性的手握和下肢肌肉强度显著降低.
- 在IMRD男性和对照人群之间没有观察到手握强度的显著差异.
- 类风湿性关节炎的肌肉强度低与年龄,疾病活动,持续时间和身体功能有关;在系统性红斑狼中也发现了类似的关联.
结论:
- 患有IMRD的个体通常表现出比健康个体更低的肌肉力量.
- 肌肉力量的减少与疾病持续时间的延长,疾病活动的增加和身体功能受损适度相关.
- 制定有针对性的干预措施对于解决和预防IMRD患者肌肉衰弱至关重要.
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