在怀孕期间患有高血糖症的妇女中,种族特异的口服葡萄糖耐受性 (OGTT) 现象
Yu Bin Tan1, Phaik Ling Quah2,3, Kok Hian Tan2,3
1Duke-NUS Medical School, Singapore yubin.tan@u.duke.nus.edu.
BMJ open diabetes research & care
|October 4, 2024
概括
这项研究揭示了不同东南亚种族的高血糖症孕妇口服葡萄糖耐受性测试 (OGTT) 独特的模式. 了解这些特定于种族的OGTT表型对于管理妊娠糖尿病至关重要.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 临床生物化学 临床生物化学
背景情况:
- 在东南亚人群中,口服葡萄糖耐受性测试 (OGTT) 表型的种族差异研究不足,特别是在怀孕时高血糖症 (HIP) 的女性中.
- 孕期糖尿病 (GDM) 的诊断和管理可能会受到特定种族的代谢特征的影响.
研究的目的:
- 研究在被诊断为HIP的女性中,种族和特定的OGTT表型之间的关联.
- 在一个多民族的亚洲人口中识别与种族相关的独特葡萄糖代谢模式.
主要方法:
- 根据国际糖尿病与怀孕研究小组协会 (IADPSG) 的标准,对3027名孕妇进行了回顾性分析,其中508名孕妇被诊断患有HIP.
- 将OGTT表型分为四组,根据0,1,2小时或多个时间点的异常葡萄糖水平.
- 多项逻辑回归分析调整为母亲的年龄,平价值和第一季度的BMI.
主要成果:
- HIP患病率为16.8%,印度 (20.5%),中国 (18.3%) 和马来 (14.2%) 妇女的患病率最高.
- 与马来妇女相比,印度和中国妇女的仅禁食OGTT表型风险明显更高.
- 与马来西亚妇女相比,中国妇女患食后2小时OGTT表型的风险增加.
结论:
- 不同的OGTT表型与在亚洲多民族环境中发展HIP的女性中不同族群有关.
- 这些发现凸显了在诊断和治疗高血压患者时考虑特定种族的葡萄糖代谢模式的重要性.
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