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Updated: Jun 13, 2025

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转移性尿路细胞癌的基因组和转录组景观

Yohann Loriot1,2,3, Maud Kamal4, Laurene Syx5

  • 1Gustave Roussy, DITEP, Gustave Roussy, Villejuif, France. yohann.loriot@gustaveroussy.fr.

Nature communications
|October 4, 2024
PubMed
概括

转移性尿路细胞癌 (mUC) 与初级UC具有共同的基因组特征. 关键发现揭示了流行突变特征,并在73%的患者中确定了可操作的目标,包括FGFR3和ERBB2的改变.

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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