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Plekhg5控制了Sod1的非传统分泌,通过前突触分泌自

Amy-Jayne Hutchings1, Bita Hambrecht1, Alexander Veh1

  • 1Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany.

Nature communications
|October 4, 2024
PubMed
概括

在神经元中,Plekhg5蛋白促进Sod1的非传统蛋白质分泌 (UPS). 运动神经元疾病模型中的Plekhg5功能受损会破坏Sod1分泌,影响疾病的进展.

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