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Updated: Jun 12, 2025

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对 Sir2 相关的短 prokaryotic Argonaute 免疫系统的四重化依赖激活

Ning Cui1, Jun-Tao Zhang1, Zhuolin Li1

  • 1Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.

Nature communications
|October 4, 2024
PubMed
概括

作为SPARSA免疫系统的一部分的Prokaryotic Argonaute (pAgo) 蛋白质,形成四聚体来激活NADase活动. 这种机制通过耗尽NAD+并触发细胞死亡来防御入侵者.

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