在欧洲一般成年人口中,脉冲波速度,增强指数,前进和后退波的振幅的参考方程
Mohammad Azizzadeh1,2, Ahmad Karimi3,4, Robab Breyer-Kohansal3,5
1Ludwig Boltzmann Institute for Lung Health, Vienna, Austria. mohammad.azizzadeh@leadstudy.at.
Scientific reports
|October 4, 2024
概括
这项研究在大量人群中确定了四种脉动性血液动力学标志物的参考方程. 这些方程标准化了测量,有助于解释血管衰老和心血管事件风险.
科学领域:
- 心血管生理学心血管生理学
- 生物统计学 生物统计学
- 人口健康 人口健康
背景情况:
- 脉动性血液动力学是心血管事件的关键预测因素.
- 对于临床应用,需要对这些标记物的标准化解释.
- 现有的参考范围可能无法充分捕捉特定种群的变化.
研究的目的:
- 描述四个脉动性血液动力学标记:带-股骨脉冲波速度 (cfPWV),增强指数 (AIx),前进波幅 (Pf) 和后退波幅 (Pb).
- 通过使用Lambda-Mu-Sigma (LMS) 方法,为这些标记物开发性别和年龄特定的参考方程.
- 为了使脉动性血液动力学能够进行标准化和准确的解释,以评估血管衰老.
主要方法:
- 利用了来自奥地利LEAD队列研究的6828名参与者的数据,但不包括患有心血管疾病或相关并发症的人.
- 在不同年龄类别和性别中测量cfPWV,AIx,Pf和Pb.
- 应用LMS方法,为血液动力学参数创建性别和年龄特定的参考方程.
主要成果:
- 所有四个脉动性血液动力学参数 (cfPWV,AIx,Pf,Pb) 都显示随着年龄的增长而增加.
- 观察到显著的性别差异:cfPWV和Pf在男性中更高,而AIx在所有年龄段的女性中更高.
- 在40岁以上的个体中,女性的Pb比男性高.
- 开发了参考方程和在线工具来计算性别和年龄标准化的z-scores.
结论:
- 衍生的参考方程为在大量人群中标准化脉动性血液动力学测量提供了强大的工具.
- 这些标准化值有助于准确解释血管衰老和心血管风险评估.
- 这些发现强调了在评估脉动性血液动力学时考虑性别和年龄的重要性.
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