高频超声波和剪切波弹性成像在全身性硬化症中的诊断价值和临床相关性:一项观察性单心研究
Shengnan Yu1, Haiting Peng1,2, Xiaoyun Yang3
1Department of Rheumatology and Immunology, The First People's Hospital of Yunnan Province, The affiliated hospital of Kunming University of Science and Technology, Jinbi Road, No.157, Kunming, 650032, Yunnan Province, China.
Clinical rheumatology
|October 4, 2024
概括
高频超声波 (HFU) 和剪切波弹性图 (SWE) 有效地检测系统性硬化症 (SSc) 的皮肤变化. 这些超声波技术在区分SSc患者和健康个体方面表现出很高的准确性.
科学领域:
- 类风湿病学 类风湿病学
- 医疗成像医学成像
- 皮肤病学 皮肤病学
背景情况:
- 系统性硬化症 (SSc) 的特征是皮肤受影响.
- 准确评估皮肤变化对于诊断和管理至关重要.
- 非侵入性成像技术可能为SSc病理生理学提供有价值的见解.
研究的目的:
- 调查高频超声波 (HFU) 和剪切波弹性图 (SWE) 在特征性皮肤变化的SSc患者的实用性.
- 评估HFU和SWE在区分SSc患者与健康对照 (HCs) 的能力.
- 为了将超声波发现与临床疾病严重程度相关联.
主要方法:
- 一项涉及20名SSc患者和20名匹配的HCs的横截面研究.
- 使用高频超声波 (HFU) 和剪波弹性图 (SWE) 来测量皮肤厚度和硬度.
- 使用接收器操作特征 (ROC) 曲线分析来评估诊断性能.
- 使用修改后的罗丹皮肤评分 (mRSS) 进行了相关性分析.
主要成果:
- 与HC相比,SSc患者的皮肤厚度和硬度显著增加.
- 在患有高疾病活性的患者中观察到更高的皮肤厚度和硬度.
- 超声波技术显示出高的诊断准确性,HFU和SWE组合实现了0.980.98的ROC曲线下的面积 (AUC).
- 在超声波测量和mRSS之间发现了显著的正相关性.
结论:
- HFU和SWE是评估SSc.皮肤参与的有价值的工具.
- 这些超声波模式显示出区分SSc患者和HC患者的绝佳潜力.
- 超声波测量与临床疾病严重程度相关,支持其在SSc管理中的作用.
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