双胞胎怀孕和产后出血:一个系统审查和元分析
Fatma A M Abdulsalam1, Natalie E Bourdakos2,3, James W F Burns4
1Milton Keynes University Hospital, Milton Keynes, MK6 5LD, UK. Abdulsalam.f@live.sgul.ac.cy.
BMC pregnancy and childbirth
|October 4, 2024
概括
产后出血 (PPH) 影响超过10%的阴道双胞胎分娩和27%的剖腹产. 试管婴儿 (IVF) 在双胞胎怀孕中很常见,可能会增加PPH风险.
科学领域:
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产科 产科 产科 产科 产科
- 生殖健康 生殖健康
背景情况:
- 产后出血 (PPH) 是导致产妇死亡的主要原因.
- 双胞胎怀孕的PPH风险比单胎怀孕更高.
研究的目的:
- 为了确定双胞胎怀孕中PPH的发生率.
- 分析双胞胎怀孕中与PPH相关的孕产妇和产周特征.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Cochrane,Scopus,Web of Science) 进行全面的文献搜索,截至2023年6月.
- 21项研究的元分析,包括23,330例双胞胎怀孕.
- 使用通用的逆方差方法进行聚合分析;PROSPERO注册 (CRD42023427192).
主要成果:
- 阴道分娩的PPH发病率为10.9%,剖腹产发病率为27.0%.
- 在62.0%的病例中,体外受精 (IVF) 是受孕方法.
- 81.1%的双胞胎是二二的.
结论:
- 在双胞胎怀孕中观察到高比例的PPH,特别是在CS之后.
- 试管婴儿是这个队列中普遍存在的受孕方法,可能与PPH风险增加有关.
- 需要进一步进行高质量的研究来证实这些发现并指导临床实践.
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