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消化管切除术后7天的累积炎症反应预测了癌症复发的可能性
Yoshinori Fujiwara1, Shunji Endo2, Masaharu Higashida2
1Department of Digestive Surgery, Kawasaki Medical School, 577 Matsushima Kurashiki-City, Okayama, 701-0192, Japan. yyfujiwara@med.kawasaki-m.ac.jp.
BMC surgery
|October 4, 2024
概括
消化管切除术7天后C反应性蛋白 (CRP) 水平升高表明消化管癌患者的生存率不佳. 监测CRP有助于预测并发症并改善结果.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 炎症生物标志物 炎症生物标志物
背景情况:
- 研究术后系统性炎症与癌症存活率之间的联系至关重要.
- 开发了一种方法来预测食道癌症,使用C反应蛋白 (CRP) 曲线下的区域 (AUC) 切断值在食道切除术后的7天和14天.
研究的目的:
- 为了确定食道癌症中手术后CRP水平的预后切断值.
- 为了将CRP水平与临床病理特征和患者生存结果相关联.
主要方法:
- 评估了125名患有食道状细胞癌 (SCC) 的患者,接受食道切除术.
- 在14天内分析了手术后的CRP水平,计算了第7天和第14天的AUC.
- 确定截止值:CRP 7天 (CRP 7d) 在599 mg/L和CRP 14天 (CRP 14d) 在1153 mg/L.
主要成果:
- 较低的CRP 7d水平与明显更好的无复发存活率 (RFS) 和整体存活率 (OS) 相相关.
- 3,10和14个术后天 (POD) 的较高CRP水平与较低的OS率和术后并发症增加有关.
- pTNM阶段,瘤入侵深度,位置,淋巴结参与和CRP 7d是显著的预后因素;pTNM,瘤位置和CRP 7d是RFS和OS的独立预后因素.
结论:
- 早期发现和治疗术后并发症可以减轻CRP升高.
- 控制早期的CRP升高可能会改善食道癌症患者的长期预后后食道切除术.
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