白质中的结构功能合揭示了自闭症谱系障碍中的低连接性
Peng Qing1, Xiaodong Zhang1, Qi Liu1
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Molecular autism
|October 4, 2024
概括
自闭症谱系障碍 (ASD) 涉及改变的白质 (WM) 结构-功能合. 这项研究发现ASD的广泛减少,与症状严重程度相关,并改善了预测模型.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 发育障碍 发育障碍 发展障碍
背景情况:
- 自闭症谱系障碍 (ASD) 与大脑灰质变化有关.
- 白物质 (WM) 在ASD中的结构-功能合尚未得到充分探索.
研究的目的:
- 调查白质 (WM) 在自闭症谱系障碍 (ASD) 中的结构功能合.
- 检查WM合变化与ASD症状严重程度之间的关系.
- 评估用于ASD预测的综合多模型特征的有效性.
主要方法:
- 综合扩散张力成像 (DTI) 和功能连接性MRI数据来自89名ASD和63名典型发展 (TD) 个体 (ABIDE-II).
- 在一个独立的队列中,利用监督机器学习来评估WM合和ASD严重程度 (自闭症诊断观察表-2) 之间的关联.
- 比较多模型 (结构功能合) 与单模型 (仅结构或功能) 的功能性能.
主要成果:
- 与TD个体相比,ASD个体在WM结构功能合中表现出广泛的减少,特别是在指导,协会和投影区域.
- 机器学习在一个独立的测试队列中发现了改变WM合和ASD严重程度得分之间的显著相关性.
- 综合多模型特征在预测自闭症严重程度方面表现优于单模型特征.
结论:
- 这项研究提供了关于ASD个体白质中非典型结构功能合的新证据.
- 这些发现增强了对ASD病理生理学中的白质网络功能障碍的理解.
- 突出了组合结构和功能数据在ASD研究和临床应用中的潜力.
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