新生儿手术前局部消毒剂:评估皮肤损伤风险因素的系统审查
Carly Mulinda1, Sana Suhail2, Bronwyn Sutherland3
1Columbia University Vagelos College of Physicians & Surgeons, New York, New York, USA.
Pediatric dermatology
|October 5, 2024
概括
新生儿重症监护室 (NICU) 的婴儿,特别是极度早产和出生体重非常低的婴儿,面临着局部消毒剂造成皮肤损伤的高风险. 需要进一步的研究来制定更安全的指导方针.
科学领域:
- 新生儿皮肤病学 新生儿皮肤病学
- 在医疗保健机构的感染控制.
- 儿科皮肤健康儿童皮肤健康
背景情况:
- 局部消毒剂的使用对于预防新生儿重症监护室 (NICU) 的医院感染至关重要.
- 目前的消毒剂可以损害新生儿皮肤的完整性,缺乏基于证据的指导方针.
- 本综述确定了与新生儿局部消毒剂相关的皮肤损伤的风险因素和类型.
研究的目的:
- 系统地审查和描述导致新生儿皮肤损伤的风险因素.
- 为了确定新生儿局部消毒剂使用导致的皮肤损伤类型.
- 为易受伤害的婴儿制定更安全的消毒剂协议提供信息.
主要方法:
- 在主要的医学数据库 (Medline Ovid,Embase,Web of Science,CINAHL,Cochrane Library) 中进行了全面的系统文献搜索.
- 纳入标准集中在学术文献中,报告了新生儿皮肤损伤与NICU的局部抗菌剂有关.
- 对已识别的研究进行了数据提取和合成.
主要成果:
- 涉及99名新生儿的19篇文章符合纳入标准.
- 极度早产婴儿 (98.1%) 和出生时体重非常低的婴儿 (98.4%) 最受影响.
- 赫西丁 (74.8%) 是最常见的与不良事件相关的药物,包括红血热 (40.1%),皮肤损伤 (23.4%) 和化学烧伤 (17.5%).
结论:
- 极度早产和出生体重非常低的婴儿对抗菌剂诱导的皮肤毒性敏感性增加.
- 这些发现突出了研究的迫切需要,以制定指导方针,尽量减少新生儿的阴性皮肤损伤.
- 由于数据有限,目前对两个月以下婴儿的建议是不够的,需要集中调查.
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