患有自闭症儿童症状严重性的纵向变化:来自ELENA队列的结果
Florine Dellapiazza1, Cécile Rattaz1, Cécile Michelon1
1Centre de Ressources Autisme Languedoc-Roussillon et Centre d'Excellence sur l'Autisme et les Troubles du Neurodéveloppement (CeAND), CHU Montpellier, Montpellier, France.
概括
自闭症谱系障碍 (ASD) 症状的严重程度随着时间的推移而有很大变化,许多儿童表现出改善,特别是在社会影响方面. 早期诊断和年轻年龄与更好的社会结果有关,而受限制的行为需要有针对性的治疗.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科心理学 儿科心理学
- 临床研究 临床研究
背景情况:
- 自闭症谱系障碍 (ASD) 是一种终身的神经发育状况,需要持续支持.
- 了解随着时间的推移症状的变化对于有效的干预至关重要.
- 之前的研究经常表明ASD症状严重程度的稳定性.
研究的目的:
- 在一个大型儿科队列中,在三年内调查ASD症状严重程度的变化.
- 确定影响这些严重程度变化的因素.
- 探索自闭症症状变化的不同轨迹.
主要方法:
- 在基线和3年后评估了575名被诊断患有自闭症的儿童 (2-12岁) 的队列.
- 用自闭症诊断观察表-2 (ADOS-2) 来进行评估.
- 分析了ADOS对总体,社会影响 (SA) 和限制/重复行为 (RRB) 的校准严重性得分 (CSS) 的变化.
主要成果:
- 出现了四种不同的严重程度模式:稳定的高,稳定的低,增加和减少.
- 一半的样本显示了ASD总严重程度的变化:21.9%增加,29.1%减少.
- 在SA的改善与年轻的年龄和早期诊断有关,而RRB显示变化较小,没有相关因素.
结论:
- 自闭症症状严重程度表现出显著的变化,与总体稳定的发现相反.
- 社会影响症状的改善比限制行为变化更为常见.
- 需要专门针对限制性和重复性行为的治疗方法,以及早期诊断对社会结果的好处.
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