甲状腺厚度和血液流动的变化,以应对甲状腺剥夺引起的近视和重复的低水平红光疗法在几内亚猪
Aiqun Xiang1, Hong He2, Anzhen Li1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou, China.
概括
重复的低水平红光 (RLRL) 治疗成功地减缓了几内亚猪中缺形近视 (FDM) 的进展. 这种近视治疗可能通过改善胆道血流来起作用,为近视管理提供了潜在的新方法.
科学领域:
- 眼科和视觉科学 眼科和视觉科学
- 眼睛疾病的动物模型.
背景情况:
- 缺形近视 (FDM) 是一种严重的眼部疾病.
- 了解近视的进展机制对于开发有效的治疗方法至关重要.
- 冠状腺厚度和血流与折射发育有关.
研究的目的:
- 为了研究重复的低水平红光 (RLRL) 治疗对FDM的几内亚猪模型中的眼光折射发育的影响.
- 为了评估在RLRL治疗下胆道厚度 (ChT) 和胆道血流的变化.
- 评估RLRL治疗作为近视干预的潜力.
主要方法:
- 28只3周大的雄性三色试验猪被分为正常控制 (NC),缺形 (FD) 和红光处理缺形 (RLFD) 组.
- 眼镜折射和轴长度 (AL) 在3周内进行了监测.
- 光学连贯性断层扫描血管造影 (OCTA) 用于测量心血管,血管密度和血液流动信号强度 (流量) 在胆囊和中大血管层.
主要成果:
- 与NC相比,FD组表现出显著的近视和增加的AL (p < 0.001).
- 与FD组相比,RLFD组显示出高视度和减少AL (p < 0.001),表明近视进展的延迟.
- 在第2和第3周,RLRL治疗导致RLFD组与FD组相比,RLFD组的冠状腺厚度增加 (p < 0.001).
- RLFD组在第3周 (p <0.05) 显示了血管骨密度和胆囊层的流量得到改善.
- 胸膜厚度的变化与胸膜血管和血流的变化正相关 (p < 0.05).
结论:
- 重复的低水平红光 (RLRL) 疗法有效地延缓了几内亚猪中形状丧失近视的进展.
- RLRL的治疗效果可能由增强的冠状动脉血流,特别是在choriocapillaris层中介.
- RLRL疗法为近视控制提供了一个有希望的策略.
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