精神分裂症电治疗后复发:系统性审查和元分析.
Nobuatsu Aoki1,2,3, Aran Tajika4, Taro Suwa5
1Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, Osaka, 570-8506, Japan.
Schizophrenia bulletin
|October 5, 2024
概括
电疗法 (ECT) 后精神分裂症复发很常见,超过一半的患者在两年内复发. 复发风险在前六个月是最高的,特别是在急性ECT后的最初三个月.
科学领域:
- 精神病学是一个精神病学.
- 神经学 神经学
- 临床心理学 临床心理学
背景情况:
- 在急性电疗法 (ECT) 后,关于精神分裂症复发率的证据有限.
- 在治疗精神分裂症后的复发比例上缺乏明确的共识.
- 这项研究解决了对精神分裂症复发后急性ECT的纵向数据的需求.
研究的目的:
- 提供关于急性电疗法 (ECT) 后精神分裂症复发的纵向信息.
- 量化精神分裂症急性ECT后不同时间点的复发比例.
- 调查维持治疗对复发率的影响.
主要方法:
- 随机对照试验 (RCT) 和观察性研究的系统审查和元分析.
- 包括关于急性后ECT复发和精神分裂症和相关疾病的再住院的研究.
- 使用随机效应模型计算3,6,12和24个月的聚合复发估计值.
主要成果:
- 包括29项研究 (3876名患者),RCT偏差风险低.
- 在3,6,12和24个月的复发比例分别为24%,37%,41%和55%.
- 当继续/维持ECT与抗精神病药物相结合时,6个月复发比例为20%.
结论:
- 急性ECT后的精神分裂症复发主要发生在前6个月内,特别是前3个月.
- 复发率在6个月后稳定,但超过50%的患者在2年内复发.
- 需要进一步的研究来优化精神分裂症的急性后ECT治疗策略.
相关概念视频
Electroconvulsive Therapy
28
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
28
Psychosis and Antipsychotic Drugs: Overview
187
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
187
Arteries of the Lower Limbs
181
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
181
Psychosis: Goals of Pharmacotherapy
110
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
110
Mania and Antimanic Drugs: Overview
139
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
139
Schizophrenia
72
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
72


