免疫检查点抑制剂治疗期间的血栓栓塞:频率和风险因素
Takayuki Ide1, Taisuke Araki2, Tomonobu Koizumi3
1Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi Matsumoto-Shi, Nagano, 390-8621, Japan.
Discover oncology
|October 5, 2024
概括
血栓栓塞栓症 (TE) 在接受免疫检查点抑制剂 (ICI) 的患者中比预期更频繁地发生. 脱脂症和高可拉纳分数是该人群中TE的主要危险因素.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 血栓塞栓症 (TE) 是一种已知的化疗并发症.
- 免疫检查点抑制剂 (ICI) 的TE风险尚未得到充分确立.
- 本研究研究了ICI治疗的患者中TE发生率和风险因素.
研究的目的:
- 在接受免疫检查点抑制剂 (ICI) 的患者中确定血栓栓塞 (TE) 的发生率.
- 在接受ICI治疗的患者中识别与TE相关的风险因素.
- 在接受ICI治疗的癌症患者中为TE提供临床监测和管理策略的信息.
主要方法:
- 在548名接受至少一种ICI治疗的患者中进行了回顾性图表调查.
- 收集的数据包括人口统计,病史,实验室值和药物细节.
- 在ICI启动后发现了TE事件 (静脉和动脉).
主要成果:
- 总共有38个TE事件 (6.9%) 被观察到,包括22个静脉血栓栓塞 (VTE) 和16个动脉血栓塞 (ATE).
- 对TE的显著危险因素包括失脂症 (OR2.44) 和Khorana评分≥2 (HR2.40).
- 患有TE和没有TE的患者的整体存活率没有显著差异.
结论:
- 用ICI治疗的患者中TE的发病率高于以前的假设.
- 临床医生应积极监测并考虑接受ICI的患者的TE.
- 识别患有脱脂症和高可拉纳分数等危险因素的患者对于主动管理至关重要.
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