老年患者癌症免疫疗法的毒性:年龄是否有所不同?
1The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, M20 4BX, UK.
Drugs & aging
|October 5, 2024
概括
免疫检查点抑制剂越来越多地用于老年人,但它们的安全性和副作用管理需要进一步研究. 需要进行研究,以优化它们在老年瘤学中的使用.
科学领域:
- 老年瘤学 老年瘤学
- 免疫治疗是一种免疫疗法.
- 临床试验 临床试验
背景情况:
- 免疫检查点抑制剂 (ICI) 是广泛使用的癌症免疫疗法.
- 老年人是一个不断增长的ICI治疗患者群体.
- 由于在临床试验中代表性不足,对ICI在老年人中的安全性和有效性存在有限的数据.
研究的目的:
- 审查ICI在老年人中的安全性.
- 在这个人群中识别与免疫相关的不良事件 (irAEs) 管理的挑战.
- 突出老年瘤学未来研究领域.
主要方法:
- 关于ICI在老年癌症患者中的使用现有文献的审查.
- 分析安全数据和与免疫相关的不良事件.
- 讨论老年人中IRAE的管理策略.
主要成果:
- 有证据表明,ICI irAE发病率可能不会在老年人中更高,但概况可能会有所不同.
- 由于并发症和生理储备的减少,老年患者的irAEs的管理是复杂的.
- 对irAEs的皮质类固醇使用在这个人群中存在风险.
结论:
- 进一步的研究对于了解老年人ICI安全性至关重要.
- 鉴定免疫衰老的特征和确定irAEs的预测生物标志物是必不可少的.
- 改善临床试验的表现和分析现实世界的数据将增强老年瘤患者的治疗决策.
相关概念视频
Tumor Immunotherapy
489
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
489
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cancer Vaccines
345
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
345
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Pulmonary Tuberculosis I
221
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
221


