在患有高血压的年轻人中表型化功能:非洲PREDICT研究
Anja Degenaar1, Ruan Kruger1,2, Adriaan Jacobs1,2
1Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
Journal of clinical hypertension (Greenwich, Conn.)
|October 5, 2024
概括
年轻成年人的高血压与较低水平的功能生物标志物有关,如尿白蛋白与肌素的比率和尿素. 在这个人群中,高血压可能表明早期损伤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管医学 心血管医学
- 高血压研究 高血压研究
背景情况:
- 功能生物标志物与老年人和患有现有疾病的人的血压有关.
- 在患有高血压的年轻成年人中,关于脏生物标志物的数据有限.
研究的目的:
- 在正常血压和高血压的年轻人之间比较功能生物标志物水平.
- 在这些群体中检查这些生物标志物与血压之间的关联.
主要方法:
- 对1055名年轻成年人 (平均年龄24.6岁) 的横截面研究.
- 使用24小时血压监测进行分类高血压 (2018年ESC/ESH指南).
- 测量了膜过率,尿中的白蛋白,α-1微型血球蛋白 (uA1M),中性粒细胞凝酶相关的脂卡林 (uNGAL),尿素 (uUMOD) 和CKD273分类器.
主要成果:
- 高血压组比正常血压组显示出较低的尿白蛋白与肌素比率 (uACR),uNGAL/Cr和uUMOD/Cr.
- 在高血压患者中,24小时的缩血压 (SBP),腹缩血压 (DBP) 和平均动脉压 (MAP) 与uA1M/Cr.积极相关.
- 在高血压患者中,24小时MAP与uACR积极相关.
- 探索性分析显示,高血压组中24小时DBP/MAP和管状生物标志物之间存在积极的关联.
结论:
- 年轻成年人的高血压与功能生物标志物概况的改变有关.
- 在高血压中 perfusion 压力升高可能导致近道管损伤和早期功能下降.
- 这些发现强调了监测年轻高血压患者脏健康的重要性.
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