亚临床左心室功能障碍和性结肠炎儿童活动的实验室预测指标:一个单中心研究
Ahmed Said Behairy1, Gehan Hussein1, Ahmed Afifi2
1Pediatrics Department, Cairo University, Cairo, Egypt.
Journal of paediatrics and child health
|October 5, 2024
概括
三维斑点跟踪回声心脏学 (3D STE) 检测了性结肠炎 (UC) 儿童的亚临床心脏功能障碍. 传统方法没有发现这些心脏变化,血液标记物也没有显著差异.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
背景情况:
- 性结肠炎 (UC) 可以影响多个器官系统,包括心血管系统.
- 在患有UC的儿童中,可能会出现亚临床心脏功能障碍,但其检测和与疾病活动的关系需要进一步调查.
研究的目的:
- 在患有性结肠炎 (UC) 的儿科患者中检测亚临床心脏功能障碍.
- 评估绝对单细胞计数 (AMC) 和淋巴细胞与单细胞比率 (LMR) 与UC疾病活性之间的关联.
- 评估先进的心声回声技术在识别儿科UC心脏功能障碍中的有用性.
主要方法:
- 招募了被诊断患有UC的儿童队列和健康的对照组.
- 参与者接受了临床评估,血液测试 (包括全血计,LMR和ESR),以及使用2D,M模式,组织多普勒和3D斑点跟踪回声心脏图 (STE) 的综合回声心脏图.
- 使用儿科UC活动指数量化疾病严重程度.
主要成果:
- 与对照人群相比,患有UC的儿童的红细胞沉率 (ESR) 显着更高.
- 在UC患者中,单细胞计数,血小板计数和左心室终端-透缩直径之间发现了积极的相关性.
- 在患有UC的儿童中,三维STE显示出明显较低的射出分数和左心室缩功能受损,这些发现无法通过传统心声回声检测.
结论:
- 三维STE是一种敏感的工具,用于检测UC儿童的亚临床左心室缩功能障碍,超过传统心声回声.
- 绝对单细胞计数 (AMC) 和淋巴细胞对单细胞比率 (LMR) 在儿科UC患者和健康对照人群之间没有显著差异.
- 这些发现突显了儿科UC中亚临床心脏参与的潜力以及3D STE的先进诊断能力.
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