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Updated: Jun 11, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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基切除修复途径调节了胰腺管道腺癌中的转录复制冲突

Fan Meng1, Tiane Li2, Anup K Singh3

  • 1Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

Cell reports
|October 5, 2024
PubMed
概括

转录复制冲突 (TRCs) 在胰腺癌中常见,原因是瘤突变. 抑制基切割修复 (BER) 途径可增强TRC和DNA损伤,为胰腺管腺癌 (PDAC) 提供潜在的治疗策略.

关键词:
在ATR路径的ATR路径.CP: 癌症 癌症 癌症科普:分子生物学 分子生物学修复DNA的修复DNA的修复在R-Loop中使用.基础切除修复的基础切除修复基因诱导的复制应激反应胰腺癌是一种癌症.复制压力是复制的压力.转录复制冲突的发生.

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