深度ResBat:深度剩余批量协调,考虑共变量分布差异
Lijun An1, Chen Zhang1, Naren Wulan1
1Centre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Electrical and Computer Engineering, National University of Singapore, Singapore; Department of Medicine, Healthy Longevity Translational Research Programme, Human Potential Translational Research Programme & Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; N.1 Institute for Health, National University of Singapore, Singapore.
在不同地点协调MRI数据至关重要. 新的深度学习方法DeepResBat和coVAE通过计算共变量来提高协调性,DeepResBat表现出卓越的性能并避免与coVAE不同的是错误的阳性.
科学领域:
- 神经成像分析分析神经成像分析
- 医疗数据协调与协调
- 机器学习在神经科学中的应用
背景情况:
- 从多个站点汇集MRI数据需要协调,以减少站点间的变化.
- 像ComBat这样的传统方法使用混合效应模型,而像cVAE这样的深度学习方法正在出现.
- 当前的深度学习方法往往忽略了共变量分布差异,可能导致低于最佳的协调.
研究的目的:
- 开发和评估基于深度学习的新型MRI协调方法,明确考虑共变量.
- 将共变量意识深度学习方法的性能与现有方法进行比较.
- 解决当前深度学习协调技术在共变量处理方面的局限性.
主要方法:
- 提出了两个共变量意识深度学习协调方法:共变量 VAE (coVAE) 和DeepRes.Bat.
- coVAE通过将共变量纳入潜伏表示来扩展cVAE.
- DeepResBat使用剩余框架,首先删除共变量效应,然后网站效应,最后重新引入共变量效应.
主要成果:
- 在减少数据集差异和保持生物效应方面,DeepResBat和coVAE的表现优于ComBat,CovBat和cVAE.
- coVAE 显示了一种倾向,在MRI 数据和共变量之间幻觉虚假的关联.
- DeepResBat被证明是一个有效的深度学习替代ComBat对MRI协调.
结论:
- 共变量意识的深度学习方法可以显著改善MRI数据的协调.
- DeepResBat是一种有前途的深度学习方法,用于协调多站点MRI数据,为ComBat.Bat提供一种有效的替代方案.
- 研究人员应该小心一些深度学习协调方法 (如coVAE) 的潜在假阳性结果.
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