皮肤内电气唤起的潜能对检测退行性宫骨髓病很敏感,这表明它们在脊髓中传播
Sara U Júlio1, Miriam Schneuwly1, Paulina S Scheuren2
1Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
概括
皮内电诱发潜能 (IEEP) 在退行性宫骨髓病 (DCM) 中显示异常反应,这表明脊髓道受影响. 结合IEEP和接触热唤起潜力 (CHEP) 可能为DCM提供补充的诊断见解.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 电力生理学 电力生理学
背景情况:
- 退行性宫髓病 (DCM) 是一种脊髓疾病,主要影响交叉纤维.
- 接触热唤起的潜能 (CHEPs) 评估DCM中脊柱体管道的完整性,而体感唤起的潜能 (dSSEPs) 评估背脊功能.
- 在DCM中有害刺激后,皮肤内电唤起潜能 (IEEP) 的脊柱传播仍然不清楚.
研究的目的:
- 为了研究IEEPs在DCM患者中脊柱体道传播的情况.
- 为了比较IEEP与CHEP和dSSEP在DCM中检测脊柱病理方面的区分能力.
主要方法:
- 通过神经学检查和MRI定义的狭窄症证实了DCM的诊断.
- 通过刺激C6,C8和T4皮肤瘤来引起dSSEP,CHEP和IEEP.
- 脊柱传播通过响应一致性进行评估,并通过接收器操作特征 (ROC) 曲线对分辨力进行评估.
主要成果:
- 在43%-54%的DCM患者中,IEEPs异常,在37%-69%的CHEPs中,dSSEPs在4-12%中异常.
- 在异常IEEP和CHEP之间观察到很高的一致性 (62-69%).
- ROC分析表明,与dSSEP不同,CHEP和IEEP的区分能力很好.
结论:
- 异常IEEPs和CHEPs之间的一致性表明IEEPs通过脊柱体管传播.
- CHEP和IEEP之间的最小差异表明它们在评估DCM中脊柱体道完整性方面的潜在补充作用.
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