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Updated: Jun 28, 2026

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对HepG2/C3A球体的全转录组动态的时间表征及其毒理学影响

Chanhee Kim1, Zhaohan Zhu2, W Brad Barbazuk3

  • 1Center for Human and Environmental Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.

Toxicology letters
|October 5, 2024
PubMed
概括

3D HepG2/C3A球体在早期培养中显示有毒物质代谢增强,在7-10天左右达到峰值. 这种模型为预测毒理学提供了更好的生理相关性,在12天后细胞行为的显著转变.

关键词:
三维细胞培养的3D细胞培养细胞的增殖细胞的增殖.基因表达 基因表达 基因表达代谢过程中的代谢.TempO-Seq-Seq 是一个时间序列.

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