肺癌液体活检中的外体的ncRNAs
Md Sadique Hussain1, Gaurav Gupta2, Nehmat Ghaboura3
1Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
概括
外体非编码RNAs (ncRNAs) 在肺癌 (LC) 诊断和治疗方面表现有前途. 外体内这些分子可以在液体活检中检测到,为管理LC提供了新的非侵入性策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 外基因组是关键的细胞间通讯器,运输非编码RNA (ncRNA).
- 外体ncRNAs (exo-ncRNAs) 在细胞功能和基因表达中起着关键作用.
- 肺癌 (LC) 研究越来越多地关注非编码RNA,以获得治疗和诊断方面的进展.
研究的目的:
- 在肺癌诊断和治疗中审查xo-ncRNAs在肺癌诊断和治疗中的双重作用.
- 探索exo-ncRNAs作为LC液体活检中的非侵入性生物标志物的潜力.
- 讨论针对LC中的外型ncRNA的新型治疗策略.
主要方法:
- 对肺癌中外体非编码RNA的综合文献综述.
- 分析目前对外o-ncRNA提取和检测的方法.
- 检查特定的外型ncRNAs在LC进展和治疗耐药性的功能性作用.
主要成果:
- 外型ncRNA与肺癌的发展,转移和治疗耐药性有关.
- 特定的外型ncRNAs通过液体活检为早期LC检测提供了有前途的生物标志物.
- 向外型ncRNAs为创新的肺癌治疗方式提供了潜力.
结论:
- 外体非编码RNA代表了肺癌诊断和治疗的重要前沿.
- 对外o-ncRNA提取,分析和临床应用的进一步研究是有必要的.
- 基于液体活检的外型ncRNA检测为个性化肺癌管理提供了一种非侵入性方法.
更多相关视频
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
01:36Overview of Exosomes
2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K