在COVID-19幸存者的认知功能和大脑结构:持续症状的作用
Krupa Vakani1, Ray Norbury1, Martina Vanova2
1Division of Psychology, Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom; Centre for Cognitive and Clinical Neuroscience, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom.
Behavioural brain research
|October 5, 2024
概括
持续的COVID-19症状与大脑体积的减少有关,特别是膜,影响执行功能等认知功能. 这突显了病毒潜在的长期神经系统影响.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 经过急性COVID-19 (COVID-19的后急性后续症) 持续的症状可以显著损害大脑结构和功能.
- 认知缺陷和心理健康问题通常在长期COVID患者中被报告.
研究的目的:
- 使用磁共振成像 (MRI) 调查持续的COVID-19症状与大脑结构之间的关联.
- 评估长期COVID对认知功能,心理健康和睡眠质量的影响.
- 探索大脑区域体积与症状负载,认知表现和心理健康之间的关系.
主要方法:
- 全脑MRI对43名工作年龄的成年人进行,这些成年人有COVID-19病史.
- 使用FSL.获得区域大脑体积 (包括腹核,尾骨,骨,骨,丘脑,杏仁体,海马体,灰质,白质和脑液).
- 认知功能 (处理速度,注意力,工作记忆,执行功能,识别记忆),心理健康和睡眠质量都被评估.
主要成果:
- 较高的持续性COVID-19症状负载与较小的膜体积相关.
- 增加的症状负载与工作记忆,执行功能和识别记忆受损有关,与较差的心理健康和睡眠质量相关.
- 减少皮体积完全介导了持续的COVID-19症状和执行功能减弱之间的联系.
结论:
- 持续的COVID-19症状与结构性大脑变化有关,特别是膜体积减少.
- 布塔门体积的减少可能是长期COVID患者在执行功能中观察到的缺陷的基础.
- 需要进一步的研究来确认这些神经生物学变化及其功能后果的长期持续性.
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