对社区获得的急性损伤风险因素的前性研究
Telma H Ragnarsdotttir1, Margret Kristjansdottir2, Gisli Gislason2
1Faculty of Medicine, School of Health Sciences, University of Iceland, Iceland; Internal Medicine Services, Landspitali University Hospital, Reykjavik, Iceland.
European journal of internal medicine
|October 5, 2024
概括
社区获得的急性损伤 (CA-AKI) 经常与急性疾病和药物使用有关,特别是非类固醇抗炎药物 (NSAIDs). 频繁使用NSAID是CA-AKI发展的一个重大问题.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 临床药理学 临床药理学
背景情况:
- 社区获得的急性损伤 (CA-AKI) 在其原因和风险因素方面仍未得到充分研究.
- 了解CA-AKI发展对于有效的预防和管理策略至关重要.
研究的目的:
- 调查与社区获得的急性损伤 (CA-AKI) 发展相关的风险因素.
主要方法:
- 一项前性研究,涉及11个月的急诊室血清肌素分析.
- 基于KDIGO标准的AKI诊断;参与者和对照者 (1:2比) 根据年龄,性别和入院日期相匹配.
- 条件后勤回归分析以确定与AKI相关的因素,包括病史和药物使用 (OTC药物).
主要成果:
- AKI病例更有可能在急诊室访问前一周使用非类固醇抗炎药物 (NSAID),特别是非处方 (OTC) NSAID.
- 相关因素包括先例吐,腹,尿,使用非选择性NSAID,RAAS抑制剂,利尿剂,以及糖尿病,慢性病 (CKD) 和吸烟等先前存在的疾病.
结论:
- 急性疾病事件和药物使用,特别是OTC NSAIDs,似乎比伴随性疾病更为显著地导致CA-AKI.
- 由于潜在的严重不良反应,经常使用OTC NSAIDs是一个值得关注的关注点,需要得到临床关注.
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