抗菌活性和随机对照试验的赫西丁涂层丝在牙出血的牙上
Sireerat Sooampon1, Charit Jirojvanichakorn2, Tanapon Ratanapakorn2
1Department of Pharmacology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
International dental journal
|October 5, 2024
概括
在一项临床研究中,赫西丁覆盖的牙线有效降低了牙出血. 虽然显示出抗菌性质,但它没有显著影响牙斑积累.
科学领域:
- 牙周病学 牙周病学
- 微生物学 微生物学
- 生物材料是一种生物材料.
背景情况:
- 与牙周病的口水相比,牙线中的赫西丁存在有限的研究.
- 这项研究研究了素覆盖的牙线,以控制斑块和牙出血.
研究的目的:
- 评估赫西丁覆盖牙线在减少牙斑积累和牙出血方面的有效性.
- 为了评估赫西丁覆盖线索的体外抗菌活性和细胞毒性.
主要方法:
- 已准备的化胺覆盖线在各种度 (0%,0.12%,1%,2%).
- 通过MTT测定,通过磁盘扩散和细胞毒性对Streptococcus mutans进行抗菌活性评估.
- 对27名参与者进行了为期14天的临床试验,使用0%,0.12%或1%的赫西丁牙线,测量斑块和出血指数.
主要成果:
- 赫西丁牙线表现出对S. mutans的剂量依赖的抗菌活性.
- 2%的度显示出高的体外毒性,排除其从临床使用.
- 与对照组相比,在0.12%和1%度下显著减少牙出血 (BI),这两种度之间没有差异.
- 两组之间没有观察到斑块指数的显著降低.
结论:
- 赫西丁覆盖的牙线具有抗菌和抗牙炎的特性.
- 低至0.12%的赫西丁牙线显著减少了牙出血.
- 没有发现赫西丁牙线对牙斑积累的额外益处.
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