延缓衰老和减少全因死亡率的最佳生活方式模式:来自英国生物银行的见解
Ce Liu1, Zhaoru Yang1, Li He1
1Institute of Occupational Health and Environmental Health, School of Public Health, Lanzhou University, Lanzhou, People's Republic of China.
概括
采用抗炎饮食,定期体力活动和健康的睡眠习惯可以显著延迟生物衰老,降低死亡风险. 较高的体力活动水平显示出对减缓衰老的最大好处.
科学领域:
- 老年学与公共卫生
- 生活方式 医学 医疗
- 衰老的生物标志物
背景情况:
- 全球人口老龄化需要确定生活方式因素,以延迟老龄化和降低死亡率.
- 英国生物银行数据集被用来调查饮食,体力活动和睡眠对衰老和死亡率的影响.
研究的目的:
- 分析饮食炎症指数,身体活动和睡眠与生物衰老和全因死亡率之间的关联.
- 确定最佳的生活方式模式,以促进健康的衰老和长寿.
主要方法:
- 对超过50万英国生物库参与者的前性队列研究.
- 主观和客观的体力活动测量 (SPA,OPA),以及饮食和睡眠质量评估.
- 生物衰老量化通过恒温失调,克莱梅拉-杜巴尔方法生物年龄,表型年龄和端粒长度;来自NHS的死亡数据;使用回归和考克斯模型进行统计分析.
主要成果:
- 抗炎饮食,适度体力活动和健康的睡眠与延迟生物衰老 (科恩d:0.2740.633) 和降低死亡风险 (HR-SPA:0.690;HR-OPA:0.493) 有关.
- 观察到高体力活动 (≥3000MET-min/周) 的最佳衰老益处,超过了世卫组织的建议.
- 影响在60岁以下的个人和女性中更为明显;生物年龄和端粒长度显示出潜在的死亡风险生物标志物.
结论:
- 健康的生活方式选择,抗炎饮食,足够的体力活动和良好的睡眠对于延缓衰老和降低死亡率至关重要.
- 研究结果支持针对性干预措施,以改善公共卫生.
- 未来的研究应该优先考虑客观的生活方式评估进行验证.
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