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Updated: Jun 11, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

瘤殖民型Streptococcus mutans在代谢上重编程瘤微环境,并促进口腔状细胞癌

Jiaying Zhou^1,2, Zixuan Hu^3,4,5, Lei Wang^6,7,8

¹Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan Road West, Guangzhou, 510055, China.

|October 5, 2024

概括

口腔状细胞癌 (OSCC) 是由患者的唾液促进的, Streptococcus mutans 产生氨酸 (KYNA). KYNA促进瘤生长和免疫抑制,影响癌症的进展和治疗结果.

科学领域:

在瘤学瘤学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

口腔状细胞癌 (OSCC) 是癌症相关死亡的重要原因之一.
驱动OSCC病变的精确机制在很大程度上仍然未知.

研究的目的:

研究口腔微生物群及其代谢物在OSCC发展中的作用.
阐明口腔细菌影响瘤微环境和OSCC中的免疫反应的机制.

主要方法:

利用大鼠模型评估患者产生的唾液对OSCC进展的影响.
对唾液和瘤组织进行了代谢分析.
研究了Streptococcus mutans (S. mutans) 和金酸 (KYNA) 在OSCC中的作用.

主要成果:

与健康对照组不同的是,OSCC患者的唾液在体内促进了OSCC的发展.
在OSCC患者的唾液和瘤组织中发现了KYNA的升高水平.
内S. mutans驱动KYNA的过度生产,导致中性粒细胞扩张,IL-1β产生,CD8+T细胞耗尽和免疫抑制.
KYNA损害了PD-L1和IL-1β向治疗的疗效,与患者的生存率差相关.

结论:

异常的口腔微生物群,特别是S. mutans,可以产生像KYNA这样的上代谢物,促进OSCC.
准口腔微生物群及其代谢途径是OSCC预防和治疗的潜在策略.
该研究强调了瘤微环境和微生物代谢物在OSCC进展中的关键作用.

关键词:

口腔的微生物群.口腔状细胞癌的癌症.瘤微环境是一个微环境.

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