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在结肠癌中的饮食质量和化疗诱导的外周神经病变
Stephanie L E Compton1, Shengping Yang1, Joseph Madere1
1Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Cancer
|October 6, 2024
概括
更高的饮食质量可能会降低结肠癌幸存者的化疗诱导周围神经病变 (CIPN) 的风险. 这项研究发现,更好的饮食与较低的CIPN发病率有关,而某些食物增加了风险.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 神经科学是一个神经科学.
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是与结肠癌患者的oxaliplatin治疗相关的显著剂量限制毒性.
- 了解缓解CIPN风险的因素对于改善患者的治疗结果和治疗坚持至关重要.
研究的目的:
- 为了研究基线饮食质量和中度至重度或重度CIPN在接受氧沙治疗的结肠癌幸存者的发展之间的关联.
- 确定可能影响CIPN风险的特定饮食成分.
主要方法:
- 饮食质量通过使用127项食物频率问卷进行评估,并通过2010年替代健康饮食指数 (AHEI-2010) 获得分数.
- 使用患者报告结果版本的常用术语标准对不良事件进行了CIPN的评估.
- 考克斯的比例危险模型被用来分析饮食质量与132名接受氧沙治疗的参与者的CIPN发病时间之间的关联.
主要成果:
- 较高的整体饮食质量与中度至重度CIPN (HR,0.96;95% CI,0.93-0.99) 和重度CIPN (HR,0.91;95% CI,0.85-0.98) 的风险降低显著相关.
- 红色/加工肉类 (HR, 1.78) 和含糖饮料 (HR, 1.33) 的消费增加与中度至重度CIPN的风险更高相关.
- 更高的含糖饮料摄入量也增加了严重的CIPN风险 (HR, 1.57),而蔬菜消费显示出保护作用 (HR, 0.29).
结论:
- 较高的基线饮食质量与接受氧沙类化疗的结肠癌患者中度至重度CIPN的风险降低有关.
- 饮食修改,重点是增加蔬菜摄入量,减少红肉/加工肉类和含糖饮料的消费,这可能是预防CIPN的有价值策略.
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